The NIH has secretly engineered over 200 new gain-of-function COVID viruses, designed for heightened transmissibility, in a clandestine project at Washington University School of Medicine, as exposed in a January 15, 2025, Science Advances study. Funded by multiple NIH grants, this alarming research, conducted amid a media blackout, raises fears of another lab-leaked pandemic, with critics decrying the reckless creation of these synthetic SARS-CoV-2 variants.
Detailed in the peer-reviewed study, the experiments used advanced genetic techniques to modify the viruses, intensifying concerns as U.S. intelligence and lawmakers increasingly point to a lab-related origin for COVID-19. The high-risk pathogen research, conducted under the NIH’s oversight, has sparked outrage, with warnings that such work could unleash catastrophic consequences, prompting urgent calls for transparency and stricter controls to prevent an accidental global health crisis.
Naturalnews.com reports: The study confirms researchers used a reverse genetics system to construct the viruses, assembling genetic material not found in nature. Each pathogen was tagged with a unique six-nucleotide “barcode,” allowing scientists to track individual strains during animal experiments. According to the paper, the team pooled “>200 barcoded SARS-CoV-2 viruses” based on equal infectious viral titers.
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Notably, these synthetic constructs were created under NIH-funded biosafety level-3 (BSL-3) containment protocols — a mid-tier safeguard for dangerous pathogens. The authors emphasized that none of the lab-made viruses mirror circulating SARS-CoV-2 lineages, raising ethical concerns about the justification for their creation.
All 200+ lab-made viruses were deliberately modified to include the D614G spike mutation — a change linked to increased viral transmissibility in humans. The study notes: “We also introduced a D614G mutation in the Spike gene of SARS-CoV-2.”
Virological research has long classified D614G as a gain-of-function trait, meaning it enhances viral replication and infectivity. Prior studies found this mutation boosts replication in human lung cells and airway tissues, making viruses more efficient at infecting hosts. Critics argue that engineering pathogens with such traits — especially after the pandemic — risks repeating past mistakes.
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The NIH’s continued funding of synthetic virus research puts the agency at odds with growing scrutiny over gain-of-function studies. The White House, Congress, and intelligence agencies now concede COVID-19 likely stemmed from a lab incident involving similar work — yet taxpayer dollars still flow into projects creating novel pathogens.
Proponents argue these experiments help understand transmission, but skeptics question the necessity. “We’re building from scratch what nature didn’t, then hoping containment holds,” said one virologist familiar with the study, who requested anonymity due to the sensitivity of the topic.
As the world recovers from COVID-19’s devastation, the NIH’s latest project underscores a recurring dilemma: balancing scientific curiosity against existential risks. With over 200 enhanced viruses now confined to a lab — but backed by federal funds — the line between preparedness and peril remains dangerously thin. Whether such research advances public health or invites catastrophe may only be clear in hindsight.
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